IndiumV2, Main, Exploration, bibRecord, 000613

InP/ZnS as a safer alternative to CdSe/ZnS core/shell quantum dots: in vitro and in vivo toxicity assessment.

Identifieur interne : 000613 ( Main/Exploration ); précédent : 000612; suivant : 000614

InP/ZnS as a safer alternative to CdSe/ZnS core/shell quantum dots: in vitro and in vivo toxicity assessment.

Auteurs : RBID : pubmed:23165345

English descriptors

KwdEn :
- Animals, Cadmium Compounds (toxicity), Drosophila (drug effects), Indium (toxicity), Materials Testing, Phosphines (toxicity), Quantum Dots, Selenium Compounds (toxicity), Survival Rate, Zinc Compounds (toxicity).
MESH :
- chemical , toxicity : Cadmium Compounds, Indium, Phosphines, Selenium Compounds, Zinc Compounds.
- drug effects : Drosophila.
- Animals, Materials Testing, Quantum Dots, Survival Rate.

Abstract

We show that water soluble InP/ZnS core/shell QDs are a safer alternative to CdSe/ZnS QDs for biological applications, by comparing their toxicity in vitro (cell culture) and in vivo (animal model Drosophila). By choosing QDs with comparable physical and chemical properties, we find that cellular uptake and localization are practically identical for these two nanomaterials. Toxicity of CdSe/ZnS QDs appears to be related to the release of poisonous Cd(2+) ions and indeed we show that there is leaching of Cd(2+) ions from the particle core despite the two-layer ZnS shell. Since an almost identical amount of In(III) ions is observed to leach from the core of InP/ZnS QDs, their very low toxicity as revealed in this study hints at a much lower intrinsic toxicity of indium compared to cadmium.

DOI: 10.1039/c2nr33024e
PubMed: 23165345

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Le document en format XML

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<author><name sortKey="Brunetti, Virgilio" uniqKey="Brunetti V">Virgilio Brunetti</name>
<affiliation wicri:level="1"><nlm:affiliation>Istituto Italiano di Tecnologia (IIT), Center for Bio-Molecular Nanotechnologies@UniLe, Via Barsanti, 73010 Arnesano, Lecce, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto Italiano di Tecnologia (IIT), Center for Bio-Molecular Nanotechnologies@UniLe, Via Barsanti, 73010 Arnesano, Lecce</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chibli, Hicham" uniqKey="Chibli H">Hicham Chibli</name>
</author>
<author><name sortKey="Fiammengo, Roberto" uniqKey="Fiammengo R">Roberto Fiammengo</name>
</author>
<author><name sortKey="Galeone, Antonio" uniqKey="Galeone A">Antonio Galeone</name>
</author>
<author><name sortKey="Malvindi, Maria Ada" uniqKey="Malvindi M">Maria Ada Malvindi</name>
</author>
<author><name sortKey="Vecchio, Giuseppe" uniqKey="Vecchio G">Giuseppe Vecchio</name>
</author>
<author><name sortKey="Cingolani, Roberto" uniqKey="Cingolani R">Roberto Cingolani</name>
</author>
<author><name sortKey="Nadeau, Jay L" uniqKey="Nadeau J">Jay L Nadeau</name>
</author>
<author><name sortKey="Pompa, Pier Paolo" uniqKey="Pompa P">Pier Paolo Pompa</name>
</author>
</titleStmt>
<publicationStmt><date when="2013">2013</date>
<idno type="doi">10.1039/c2nr33024e</idno>
<idno type="RBID">pubmed:23165345</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Cadmium Compounds (toxicity)</term>
<term>Drosophila (drug effects)</term>
<term>Indium (toxicity)</term>
<term>Materials Testing</term>
<term>Phosphines (toxicity)</term>
<term>Quantum Dots</term>
<term>Selenium Compounds (toxicity)</term>
<term>Survival Rate</term>
<term>Zinc Compounds (toxicity)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Cadmium Compounds</term>
<term>Indium</term>
<term>Phosphines</term>
<term>Selenium Compounds</term>
<term>Zinc Compounds</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Drosophila</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Materials Testing</term>
<term>Quantum Dots</term>
<term>Survival Rate</term>
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<front><div type="abstract" xml:lang="en">We show that water soluble InP/ZnS core/shell QDs are a safer alternative to CdSe/ZnS QDs for biological applications, by comparing their toxicity in vitro (cell culture) and in vivo (animal model Drosophila). By choosing QDs with comparable physical and chemical properties, we find that cellular uptake and localization are practically identical for these two nanomaterials. Toxicity of CdSe/ZnS QDs appears to be related to the release of poisonous Cd(2+) ions and indeed we show that there is leaching of Cd(2+) ions from the particle core despite the two-layer ZnS shell. Since an almost identical amount of In(III) ions is observed to leach from the core of InP/ZnS QDs, their very low toxicity as revealed in this study hints at a much lower intrinsic toxicity of indium compared to cadmium.</div>
</front>
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<DateCreated><Year>2012</Year>
<Month>12</Month>
<Day>11</Day>
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<DateCompleted><Year>2013</Year>
<Month>05</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2040-3372</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>5</Volume>
<Issue>1</Issue>
<PubDate><Year>2013</Year>
<Month>Jan</Month>
<Day>7</Day>
</PubDate>
</JournalIssue>
<Title>Nanoscale</Title>
<ISOAbbreviation>Nanoscale</ISOAbbreviation>
</Journal>
<ArticleTitle>InP/ZnS as a safer alternative to CdSe/ZnS core/shell quantum dots: in vitro and in vivo toxicity assessment.</ArticleTitle>
<Pagination><MedlinePgn>307-17</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1039/c2nr33024e</ELocationID>
<Abstract><AbstractText>We show that water soluble InP/ZnS core/shell QDs are a safer alternative to CdSe/ZnS QDs for biological applications, by comparing their toxicity in vitro (cell culture) and in vivo (animal model Drosophila). By choosing QDs with comparable physical and chemical properties, we find that cellular uptake and localization are practically identical for these two nanomaterials. Toxicity of CdSe/ZnS QDs appears to be related to the release of poisonous Cd(2+) ions and indeed we show that there is leaching of Cd(2+) ions from the particle core despite the two-layer ZnS shell. Since an almost identical amount of In(III) ions is observed to leach from the core of InP/ZnS QDs, their very low toxicity as revealed in this study hints at a much lower intrinsic toxicity of indium compared to cadmium.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Brunetti</LastName>
<ForeName>Virgilio</ForeName>
<Initials>V</Initials>
<Affiliation>Istituto Italiano di Tecnologia (IIT), Center for Bio-Molecular Nanotechnologies@UniLe, Via Barsanti, 73010 Arnesano, Lecce, Italy.</Affiliation>
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<Author ValidYN="Y"><LastName>Chibli</LastName>
<ForeName>Hicham</ForeName>
<Initials>H</Initials>
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<Author ValidYN="Y"><LastName>Fiammengo</LastName>
<ForeName>Roberto</ForeName>
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<Author ValidYN="Y"><LastName>Galeone</LastName>
<ForeName>Antonio</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Malvindi</LastName>
<ForeName>Maria Ada</ForeName>
<Initials>MA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Vecchio</LastName>
<ForeName>Giuseppe</ForeName>
<Initials>G</Initials>
</Author>
<Author ValidYN="Y"><LastName>Cingolani</LastName>
<ForeName>Roberto</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Nadeau</LastName>
<ForeName>Jay L</ForeName>
<Initials>JL</Initials>
</Author>
<Author ValidYN="Y"><LastName>Pompa</LastName>
<ForeName>Pier Paolo</ForeName>
<Initials>PP</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType>Comparative Study</PublicationType>
<PublicationType>Journal Article</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2012</Year>
<Month>11</Month>
<Day>19</Day>
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</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Nanoscale</MedlineTA>
<NlmUniqueID>101525249</NlmUniqueID>
<ISSNLinking>2040-3364</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance>Cadmium Compounds</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance>Phosphines</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance>Selenium Compounds</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance>Zinc Compounds</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>045A6V3VFX</RegistryNumber>
<NameOfSubstance>Indium</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>1315-09-9</RegistryNumber>
<NameOfSubstance>zinc selenide</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>22398-80-7</RegistryNumber>
<NameOfSubstance>indium phosphide</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>A7F646JC5C</RegistryNumber>
<NameOfSubstance>cadmium selenide</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N">Cadmium Compounds</DescriptorName>
<QualifierName MajorTopicYN="Y">toxicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N">Drosophila</DescriptorName>
<QualifierName MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N">Indium</DescriptorName>
<QualifierName MajorTopicYN="Y">toxicity</QualifierName>
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<MeshHeading><DescriptorName MajorTopicYN="N">Materials Testing</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N">Phosphines</DescriptorName>
<QualifierName MajorTopicYN="Y">toxicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N">Quantum Dots</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N">Selenium Compounds</DescriptorName>
<QualifierName MajorTopicYN="Y">toxicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N">Survival Rate</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N">Zinc Compounds</DescriptorName>
<QualifierName MajorTopicYN="Y">toxicity</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2012</Year>
<Month>11</Month>
<Day>19</Day>
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<PubMedPubDate PubStatus="epublish"><Year>2012</Year>
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<Day>6</Day>
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<PubMedPubDate PubStatus="medline"><Year>2013</Year>
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</History>
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</record>

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InP/ZnS as a safer alternative to CdSe/ZnS core/shell quantum dots: in vitro and in vivo toxicity assessment.

InP/ZnS as a safer alternative to CdSe/ZnS core/shell quantum dots: in vitro and in vivo toxicity assessment.

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki